Professor and Director of Neurosurgery
Johns Hopkins University SOM
Baltimore, MD, US
HENRY BREM, M.D.
Harvey Cushing Professor
Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering
Director, Department of Neurosurgery
Director, Hunterian Neurosurgical Research Laboratory
Johns Hopkins University School of Medicine
Henry Brem has developed new tools and techniques that have changed the field of neurosurgery. Brem carried out the pivotal clinical study that introduced navigational imaging into the neurosurgical suite. His work led to the FDA's approval of the first image guidance computer system for intraoperative localization of tumors. Furthermore, he has changed the surgical armamentarium against brain tumors by inventing and developing Gliadel® wafers to intraoperatively deliver chemotherapy to brain tumors. His work with Bob Langer, has shown that surgeons can accurately deliver potent therapies directly at the tumor site.
Brem has changed the surgical treatment of brain tumors by introducing new approaches for targeted therapy. He developed new classes of polymers and microchips for drug delivery that are custom synthesized for the agent being developed. The polyanhydrides, which were the first new treatments for brain tumors that the FDA had approved in 23 years, have been shown in his laboratory to be biocompatible and potent. He then designed and led the clinical trials demonstrating safety and efficacy. He has published over 400 research papers, 58 book chapters, 11 patents, and an H index of 100 with over 42,000 citations. In addition to his academic work he has worked closely with biotech companies to develop new technologies.
The worldwide impact of the Hopkins Neurosurgery Department is reflected in 20 Neurosurgery Department Chairman that have come from the Department between 2000 and 2024.
Brem’s devotion to patient care, clinical excellence and translational science has brought together a unique group of neurosurgeons and investigators that have changed the field of neurosurgery. He continues his practice of complex brain surgery and to lead the Johns Hopkins Neurosurgery Department.
Disclosure(s): Candel Therapeutics: Consultant (Ongoing); Catalio Nexus Fund II, LLC: Consultant (Ongoing); InSightec: Consultant (Ongoing); Intragel: Consultant (Ongoing); Khatib Foundation: Grant/Research Support (Ongoing); LikeMinds, Inc.: Consultant (Ongoing); NICO Myriad Corporation: Grant/Research Support (Ongoing); NIH: Grant/Research Support (Ongoing); Nurami Medical: Consultant (Ongoing)
AANS Section on the History of Neurological Surgery Annual Dinner (2203)
Saturday, May 4, 2024
6:00 PM – 8:00 PM CT