Efficacy and Safety Assessment of LVIS JR Device in Treating Wide-Neck Aneurysms: A Comprehensive Meta-Analysis

Introduction: The treatment of wide-neck aneurysms presents a significant clinical challenge, mainly due to their complex anatomical. Despite the considerable focus on endovascular techniques in recent years, there is still a high incidence of incomplete occlusion with this approach. However, recent studies have indicated that using the LVIS (Low-profile Visualized Intraluminal Support) device offers a promising solution to address these challenges, leading to improved final occlusion rates. Nevertheless, there is a noticeable lack of comprehensive research systematically evaluating its outcomes, underscoring the need for further investigations in this area.

Methods: We systematically searched Medline, Embase, and Web of Science databases, focusing on studies involving ≥4 wide-neck aneurysm patients treated with LVIS, following PRISMA guidelines. The studies were required to assess at least one of the following outcomes: final occlusion, good clinical outcomes, and complications. Good clinical outcomes were defined for patients with a Modified Rankin Scale (mRs) score between 0 and 2.

Results: 886 studies were initially found, twenty studies, that met inclusion criteria and encompassed a total of 557 patients, were comprehensively analyzed using the random effects model. The final occlusion rate was 93% (95% CI: 88% - 97%, I² = 69%), and favorable clinical outcomes were consistently observed, with a rate of 99% (95% CI: 97% - 100%, I² = 27%). Low mortality rates were evident, with only one reported death among 499 patients across 18 studies, resulting in a 0% rate (95% CI: 0% - 1%, I² = 0%). Finally, complications were observed in 44 out of 482 patients, yielding a 6% rate (95% CI: 4% - 9%, I² = 25%).

Conclusion : The findings in this study showed a notably high final occlusion rate and positive clinical outcomes. Additionally, the low mortality rate observed underscores the potential benefits of LVIS Jr in endovascular procedures.